Human IL4- Recombinant (AF)

IL-4, a multifaceted cytokine, plays a crucial role in governing various T and B cell activities such as cell proliferation, survival, and gene expression. It is synthesized by mast cells, T cells, and bone marrow stromal cells. IL-4 specifically directs the transformation of naive CD4+ T cells into helper Th2 cells, known for their cytokine-secretion profile that includes IL-4, IL-5, IL-6, IL-10, and IL-13, all conducive to a humoral immune response. Additionally, IL-4 is pivotal in regulating the shift of immunoglobulin classes towards IgG1 and IgE isotypes. An important note is that excessive IL-4 production by Th2 cells can lead to heightened IgE production and allergic responses. The recombinant Human IL-4, a 15.1 kDa globular protein containing 130 amino acid residues, mirrors these regulatory functions in the immune system.