Human NGF- Recombinant (AF)

?-NGF, a neurotrophic factor structurally akin to BDNF, NT-3, and NT-4, is part of the cysteine-knot family of growth factors, characterized by stable dimeric structures. This potent neurotrophic factor operates via its receptor ?-NGFR, playing a pivotal role in the development and maintenance of the sensory and sympathetic nervous systems. Additionally, ?-NGF functions as a growth and differentiation factor for B lymphocytes, boosting B-cell survival. The active form of Recombinant Human ?-NGF is a non-covalently linked homodimer comprising two 13.5 kDa polypeptide monomers, each containing 120 amino acids and three disulfide bonds essential for biological activity.