Human Activin A (Animal-Free Recombinant)

Activin A a member of the TGF-? family showcases diverse biological functions including the regulation of cellular proliferation and differentiation as well as the promotion of neuronal survival. Its elevated presence in colorectal tumors in humans and in postmenopausal women has been linked to colorectal and breast cancers respectively. Inhibins and follistatin a diffusible TGF-? antagonist can counteract the biological effects of Activin A. This molecule binds to two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins can exist as homodimers or heterodimers of distinct ? subunits. Initially synthesized as precursor proteins they feature an amino terminal propeptide that is cleaved to unveil the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A manifests as a 26.0 kDa disulfide-linked homodimer comprising two ?A chains each composed of 116 amino acid residues.