Human VEGF-165 Recombinant (AF)

VEGF stands out as a potent cytokine, driving growth and angiogenesis. It fosters endothelial cell proliferation and survival, contributing significantly to angiogenesis and vascular permeability. Its expression in vascularized tissues plays a crucial role in both normal and abnormal angiogenesis. VEGF's involvement is notable in tumor metastasis induction and intraocular neovascular syndromes. VEGF signals through three receptors: fms-like tyrosine kinase (flt-1), the KDR gene product (with the murine equivalent being the flk-1 gene product), and the flt4 gene product. Recombinant Human VEGF165 is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.